Target name

O08786: Cholecystokinin receptor type A


  Protein function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

  Database links

Uniprot primary ID O08786
GRCP SARfari Variant Name mCCKAR_1311
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 76
PharmGKB ID
KEGG ID mmu:12425
Entrez Gene (Gene ID) 12425
BindingDB O08786

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.55 0.96 0.75 0.69 0.94 0.56 Download
FP4 fingerprints 0.870 0.730 0.800 0.810 0.870 0.600 Download
MACCS fingerprints 0.870 0.810 0.840 0.840 0.920 0.680 Download
Daylight fingerprints 0.770 0.910 0.840 0.830 0.920 0.680 Download
ECFP2 fingerprints 0.600 0.770 0.680 0.650 0.840 0.370 Download
ECFP4 fingerprints 0.750 0.860 0.810 0.790 0.900 0.610 Download
ECFP6 fingerprints 0.780 0.870 0.820 0.820 0.930 0.650 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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