Target name

O14842: Free fatty acid receptor 1


  Protein function

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

  Database links

Uniprot primary ID O14842
GRCP SARfari Variant Name hGPR40_59
PDB ID 4PHU
DrugBank ID DB00159
BioGrid ID
GuidetoPHARMACOLOGY ID 225
PharmGKB ID PA28887
KEGG ID hsa:2864
Entrez Gene (Gene ID) 2864
BindingDB O14842

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.92 0.88 0.9 0.91 0.95 0.81 Download
FP4 fingerprints 0.940 0.800 0.870 0.880 0.930 0.750 Download
MACCS fingerprints 0.850 0.820 0.840 0.840 0.910 0.680 Download
Daylight fingerprints 0.750 0.750 0.750 0.750 0.800 0.500 Download
ECFP2 fingerprints 0.950 0.810 0.880 0.890 0.940 0.780 Download
ECFP4 fingerprints 0.950 0.880 0.920 0.920 0.960 0.840 Download
ECFP6 fingerprints 0.950 0.880 0.910 0.920 0.960 0.830 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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