Target name

O43613: Orexin receptor type 1


  Protein function

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

  Database links

Uniprot primary ID O43613
GRCP SARfari Variant Name hHCRTR1_69
PDB ID
DrugBank ID
BioGrid ID 109311
GuidetoPHARMACOLOGY ID 321
PharmGKB ID PA29222
KEGG ID hsa:3061
Entrez Gene (Gene ID) 3061
BindingDB O43613

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.55 0.79 0.67 0.63 0.73 0.35 Download
FP4 fingerprints 0.620 0.620 0.620 0.620 0.660 0.240 Download
MACCS fingerprints 0.640 0.640 0.640 0.640 0.670 0.280 Download
Daylight fingerprints 0.570 0.730 0.650 0.620 0.690 0.310 Download
ECFP2 fingerprints 0.550 0.810 0.680 0.630 0.750 0.370 Download
ECFP4 fingerprints 0.530 0.880 0.700 0.640 0.810 0.430 Download
ECFP6 fingerprints 0.460 0.880 0.670 0.590 0.790 0.380 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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