Target name

O43614: Orexin receptor type 2


  Protein function

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

  Database links

Uniprot primary ID O43614
GRCP SARfari Variant Name hHCRTR2_70
PDB ID 4S0V
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 322
PharmGKB ID PA29223
KEGG ID hsa:3062
Entrez Gene (Gene ID) 3062
BindingDB O43614

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.65 0.88 0.77 0.74 0.89 0.55 Download
FP4 fingerprints 0.590 0.830 0.710 0.670 0.810 0.430 Download
MACCS fingerprints 0.590 0.820 0.700 0.660 0.820 0.410 Download
Daylight fingerprints 0.570 0.880 0.730 0.680 0.850 0.480 Download
ECFP2 fingerprints 0.650 0.880 0.770 0.740 0.900 0.550 Download
ECFP4 fingerprints 0.680 0.900 0.790 0.760 0.920 0.600 Download
ECFP6 fingerprints 0.490 0.910 0.700 0.620 0.920 0.440 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn