Target name

O88319: Neurotensin receptor type 1


  Protein function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity).

  Database links

Uniprot primary ID O88319
GRCP SARfari Variant Name mNTSR1_1338
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 309
PharmGKB ID
KEGG ID mmu:18216
Entrez Gene (Gene ID) 18216
BindingDB O88319

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.73 0.71 0.72 0.72 0.79 0.44 Download
FP4 fingerprints 0.710 0.740 0.720 0.720 0.770 0.450 Download
MACCS fingerprints 0.710 0.730 0.720 0.720 0.760 0.440 Download
Daylight fingerprints 0.670 0.810 0.740 0.720 0.790 0.490 Download
ECFP2 fingerprints 0.690 0.740 0.710 0.710 0.730 0.430 Download
ECFP4 fingerprints 0.690 0.790 0.740 0.720 0.760 0.470 Download
ECFP6 fingerprints 0.670 0.820 0.750 0.730 0.790 0.500 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn