Target name

O95136: Sphingosine 1-phosphate receptor 2


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

  Database links

Uniprot primary ID O95136
GRCP SARfari Variant Name hEDG5_77
PDB ID 1ZTI
DrugBank ID
BioGrid ID 114708
GuidetoPHARMACOLOGY ID 276
PharmGKB ID PA162402353
KEGG ID hsa:9294
Entrez Gene (Gene ID) 9294
BindingDB O95136

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.88 0.73 0.81 0.82 0.88 0.62 Download
FP4 fingerprints 0.720 0.780 0.750 0.750 0.800 0.510 Download
MACCS fingerprints 0.560 0.800 0.680 0.640 0.790 0.380 Download
Daylight fingerprints 0.690 0.710 0.700 0.690 0.770 0.390 Download
ECFP2 fingerprints 0.740 0.760 0.750 0.750 0.840 0.500 Download
ECFP4 fingerprints 0.830 0.820 0.820 0.830 0.890 0.650 Download
ECFP6 fingerprints 0.840 0.810 0.820 0.830 0.900 0.650 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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