Target name

O95977: Sphingosine 1-phosphate receptor 4


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

  Database links

Uniprot primary ID O95977
GRCP SARfari Variant Name hEDG6_79
PDB ID 2DCO
DrugBank ID
BioGrid ID 114243
GuidetoPHARMACOLOGY ID 278
PharmGKB ID PA162402371
KEGG ID hsa:8698
Entrez Gene (Gene ID) 8698
BindingDB O95977

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.76 0.76 0.76 0.76 0.84 0.52 Download
FP4 fingerprints 0.710 0.770 0.740 0.730 0.800 0.480 Download
MACCS fingerprints 0.620 0.810 0.720 0.690 0.780 0.440 Download
Daylight fingerprints 0.670 0.750 0.710 0.700 0.750 0.420 Download
ECFP2 fingerprints 0.770 0.770 0.770 0.770 0.830 0.540 Download
ECFP4 fingerprints 0.780 0.810 0.800 0.790 0.870 0.590 Download
ECFP6 fingerprints 0.750 0.870 0.810 0.800 0.880 0.620 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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