Target name

P06199: Muscarinic acetylcholine receptor M2


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

  Database links

Uniprot primary ID P06199
GRCP SARfari Variant Name susCHRM2_1352
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID ssc:397498
Entrez Gene (Gene ID) 397498
BindingDB P06199

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.87 0.91 0.89 0.89 0.94 0.78 Download
FP4 fingerprints 0.870 0.880 0.880 0.870 0.950 0.750 Download
MACCS fingerprints 0.900 0.920 0.910 0.910 0.930 0.820 Download
Daylight fingerprints 0.810 0.930 0.870 0.860 0.920 0.750 Download
ECFP2 fingerprints 0.910 0.860 0.890 0.890 0.920 0.780 Download
ECFP4 fingerprints 0.910 0.870 0.890 0.900 0.940 0.790 Download
ECFP6 fingerprints 0.910 0.870 0.890 0.900 0.940 0.790 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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