Target name

P07550: Beta-2 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

  Database links

Uniprot primary ID P07550
GRCP SARfari Variant Name hB2AR_84
PDB ID 3P0G 3KJ6 3NY8 3NY9 3PDS 1GQ4 3SN6 4GBR 3NYA 4LDL 3D4S 4LDO 4QKX 2RH1 4LDE 2R4R 2R4S
DrugBank ID DB01288 DB01064 DB00598 DB08808 DB00221 DB01102 DB08807 DB00321 DB00938 DB00816 DB01365 DB06262 DB00841 DB01193 DB00449 DB00871 DB01214 DB04861 DB00521 DB00852 DB00373 DB01407 DB00370 DB01136 DB00540 DB00612 DB01408 DB01363 DB00925 DB01151 DB00489 DB00668 DB00960 DB00334 DB06216 DB01295 DB00368 DB01210 DB00726 DB00397 DB01580 DB00867 DB00866 DB01203 DB01366 DB00217 DB00983 DB01291 DB01359 DB00335 DB05039 DB01274 DB01001 DB00182 DB00571 DB00264 DB00195 DB00248
BioGrid ID 106663
GuidetoPHARMACOLOGY ID 29
PharmGKB ID PA39
KEGG ID hsa:154
Entrez Gene (Gene ID) 154
BindingDB P07550

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.7 0.72 0.71 0.71 0.8 0.43 Download
FP4 fingerprints 0.800 0.600 0.700 0.730 0.760 0.400 Download
MACCS fingerprints 0.490 0.770 0.630 0.570 0.720 0.270 Download
Daylight fingerprints 0.630 0.770 0.700 0.680 0.740 0.400 Download
ECFP2 fingerprints 0.810 0.660 0.740 0.750 0.810 0.480 Download
ECFP4 fingerprints 0.810 0.720 0.770 0.780 0.850 0.530 Download
ECFP6 fingerprints 0.780 0.760 0.770 0.770 0.850 0.530 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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