Target name

P08172: Muscarinic acetylcholine receptor M2


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

  Database links

Uniprot primary ID P08172
GRCP SARfari Variant Name hCHRM2_86
PDB ID 4MQS 3UON 1LUB 4MQT
DrugBank ID DB00777 DB01142 DB01062 DB00496 DB08801 DB00321 DB01148 DB00622 DB00454 DB00280 DB00387 DB00934 DB01069 DB00462 DB01239 DB01238 DB00508 DB01231 DB00835 DB00568 DB00785 DB00408 DB06702 DB01338 DB01403 DB01135 DB01336 DB00424 DB01019 DB00420 DB00728 DB00376 DB00483 DB01151 DB00332 DB00747 DB00986 DB00334 DB00383 DB00725 DB00726 DB00202 DB00804 DB00392 DB08897 DB01036 DB00907 DB00809 DB00458 DB01337 DB00517 DB00411 DB00540 DB01221 DB01226 DB01224 DB01085 DB00715 DB00363 DB00246 DB00434 DB00340 DB00543 DB01409 DB00572 DB01591
BioGrid ID 107551
GuidetoPHARMACOLOGY ID 14
PharmGKB ID PA111
KEGG ID hsa:1129
Entrez Gene (Gene ID) 1129
BindingDB P08172

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.8 0.73 0.77 0.77 0.85 0.53 Download
FP4 fingerprints 0.810 0.700 0.760 0.770 0.820 0.520 Download
MACCS fingerprints 0.760 0.680 0.720 0.730 0.810 0.440 Download
Daylight fingerprints 0.800 0.710 0.760 0.770 0.830 0.520 Download
ECFP2 fingerprints 0.850 0.780 0.810 0.820 0.900 0.630 Download
ECFP4 fingerprints 0.850 0.840 0.850 0.850 0.920 0.690 Download
ECFP6 fingerprints 0.830 0.840 0.840 0.830 0.910 0.670 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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