Target name

P08173: Muscarinic acetylcholine receptor M4


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

  Database links

Uniprot primary ID P08173
GRCP SARfari Variant Name hCHRM4_87
PDB ID
DrugBank ID DB00777 DB01142 DB00496 DB01625 DB00321 DB00454 DB00387 DB00934 DB01239 DB01238 DB00835 DB00568 DB00785 DB00408 DB06702 DB00376 DB00622 DB00424 DB00540 DB00543 DB01151 DB00747 DB00334 DB00725 DB00726 DB01069 DB01403 DB08897 DB01036 DB00809 DB00458 DB00572 DB01221 DB01224 DB00715 DB00363 DB00246 DB00340 DB00420 DB01591
BioGrid ID 107554
GuidetoPHARMACOLOGY ID 16
PharmGKB ID PA26485
KEGG ID hsa:1132
Entrez Gene (Gene ID) 1132
BindingDB P08173

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.73 0.75 0.76 0.81 0.51 Download
FP4 fingerprints 0.720 0.660 0.690 0.700 0.770 0.380 Download
MACCS fingerprints 0.730 0.680 0.700 0.710 0.780 0.410 Download
Daylight fingerprints 0.710 0.740 0.720 0.720 0.800 0.440 Download
ECFP2 fingerprints 0.830 0.740 0.790 0.790 0.870 0.570 Download
ECFP4 fingerprints 0.830 0.800 0.820 0.820 0.900 0.630 Download
ECFP6 fingerprints 0.820 0.810 0.810 0.810 0.890 0.630 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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