Target name

P08482: Muscarinic acetylcholine receptor M1


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P08482
GRCP SARfari Variant Name rCHRM1_1353
PDB ID
DrugBank ID
BioGrid ID 247270
GuidetoPHARMACOLOGY ID 13
PharmGKB ID
KEGG ID rno:25229
Entrez Gene (Gene ID) 25229
BindingDB P08482

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.76 0.75 0.75 0.83 0.5 Download
FP4 fingerprints 0.790 0.700 0.740 0.750 0.810 0.490 Download
MACCS fingerprints 0.770 0.680 0.730 0.740 0.790 0.460 Download
Daylight fingerprints 0.640 0.700 0.670 0.660 0.720 0.330 Download
ECFP2 fingerprints 0.870 0.740 0.800 0.820 0.880 0.610 Download
ECFP4 fingerprints 0.870 0.770 0.820 0.830 0.900 0.640 Download
ECFP6 fingerprints 0.860 0.780 0.820 0.830 0.900 0.650 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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