Target name

P08483: Muscarinic acetylcholine receptor M3


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P08483
GRCP SARfari Variant Name rCHRM3_1354
PDB ID 2AMK 4U16 4DAJ 4U14 4U15
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 15
PharmGKB ID
KEGG ID rno:24260
Entrez Gene (Gene ID) 24260
BindingDB P08483

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.79 0.77 0.76 0.84 0.53 Download
FP4 fingerprints 0.760 0.700 0.730 0.740 0.810 0.460 Download
MACCS fingerprints 0.750 0.680 0.710 0.720 0.800 0.420 Download
Daylight fingerprints 0.630 0.700 0.660 0.650 0.720 0.330 Download
ECFP2 fingerprints 0.860 0.750 0.810 0.820 0.880 0.620 Download
ECFP4 fingerprints 0.900 0.770 0.830 0.840 0.900 0.670 Download
ECFP6 fingerprints 0.890 0.780 0.840 0.840 0.900 0.680 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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