Target name

P08485: Muscarinic acetylcholine receptor M4


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

  Database links

Uniprot primary ID P08485
GRCP SARfari Variant Name rCHRM4_1355
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 16
PharmGKB ID
KEGG ID rno:25111
Entrez Gene (Gene ID) 25111
BindingDB P08485

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.76 0.81 0.79 0.78 0.86 0.57 Download
FP4 fingerprints 0.790 0.740 0.770 0.770 0.840 0.530 Download
MACCS fingerprints 0.760 0.720 0.740 0.750 0.830 0.480 Download
Daylight fingerprints 0.670 0.690 0.680 0.680 0.720 0.360 Download
ECFP2 fingerprints 0.850 0.770 0.810 0.810 0.890 0.620 Download
ECFP4 fingerprints 0.880 0.790 0.840 0.850 0.910 0.680 Download
ECFP6 fingerprints 0.880 0.800 0.840 0.840 0.900 0.670 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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