Target name

P08588: Beta-1 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

  Database links

Uniprot primary ID P08588
GRCP SARfari Variant Name hB1AR_88
PDB ID 2LSQ
DrugBank ID DB01288 DB01064 DB00598 DB08808 DB00221 DB01102 DB08807 DB04855 DB00321 DB06216 DB06262 DB01193 DB00408 DB04861 DB00521 DB00852 DB00373 DB01407 DB00370 DB01136 DB00187 DB00540 DB00612 DB00182 DB01118 DB00841 DB00217 DB01151 DB00489 DB00668 DB00960 DB00334 DB01297 DB01295 DB00368 DB01210 DB00726 DB00397 DB01580 DB01363 DB00866 DB01203 DB01365 DB01291 DB01359 DB01214 DB00335 DB01001 DB00571 DB00264 DB00195 DB00248
BioGrid ID 106662
GuidetoPHARMACOLOGY ID 28
PharmGKB ID PA38
KEGG ID hsa:153
Entrez Gene (Gene ID) 153
BindingDB P08588

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.7 0.77 0.78 0.81 0.54 Download
FP4 fingerprints 0.830 0.620 0.730 0.750 0.790 0.460 Download
MACCS fingerprints 0.720 0.710 0.710 0.720 0.770 0.430 Download
Daylight fingerprints 0.750 0.710 0.730 0.730 0.780 0.460 Download
ECFP2 fingerprints 0.810 0.680 0.740 0.760 0.820 0.490 Download
ECFP4 fingerprints 0.830 0.730 0.780 0.790 0.850 0.560 Download
ECFP6 fingerprints 0.780 0.750 0.770 0.770 0.840 0.530 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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