Target name

P08908: 5-hydroxytryptamine receptor 1A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca

  Database links

Uniprot primary ID P08908
GRCP SARfari Variant Name h5HT1A_89
PDB ID
DrugBank ID DB00952 DB06148 DB01142 DB01049 DB08807 DB01622 DB00321 DB00490 DB01621 DB01200 DB04946 DB01359 DB01238 DB00216 DB00268 DB00408 DB00540 DB00960 DB00543 DB01616 DB01614 DB01151 DB00866 DB00669 DB06216 DB08810 DB00334 DB05271 DB00726 DB08815 DB01149 DB00904 DB01618 DB01392 DB01186 DB00589 DB01267 DB00458 DB00413 DB00696 DB00477 DB00315 DB01221 DB00988 DB01224 DB00734 DB00714 DB00363 DB00247 DB00246 DB00571 DB00248 DB00656 DB06684
BioGrid ID 109582
GuidetoPHARMACOLOGY ID 1
PharmGKB ID PA192
KEGG ID hsa:3350
Entrez Gene (Gene ID) 3350
BindingDB P08908

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.73 0.76 0.77 0.83 0.53 Download
FP4 fingerprints 0.830 0.670 0.750 0.770 0.810 0.510 Download
MACCS fingerprints 0.800 0.640 0.720 0.740 0.780 0.450 Download
Daylight fingerprints 0.750 0.660 0.700 0.720 0.760 0.410 Download
ECFP2 fingerprints 0.900 0.720 0.810 0.830 0.870 0.630 Download
ECFP4 fingerprints 0.900 0.810 0.850 0.860 0.920 0.710 Download
ECFP6 fingerprints 0.870 0.840 0.850 0.860 0.920 0.710 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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