Target name

P08909: 5-hydroxytryptamine receptor 2C

  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca

  Database links

Uniprot primary ID P08909
GRCP SARfari Variant Name r5HT2C_1356
DrugBank ID DB00540 DB00726
BioGrid ID
KEGG ID rno:25187
Entrez Gene (Gene ID) 25187
BindingDB P08909

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.73 0.79 0.8 0.87 0.58 Download
FP4 fingerprints 0.850 0.710 0.780 0.800 0.850 0.570 Download
MACCS fingerprints 0.770 0.670 0.720 0.740 0.800 0.450 Download
Daylight fingerprints 0.780 0.670 0.730 0.740 0.800 0.460 Download
ECFP2 fingerprints 0.880 0.770 0.830 0.840 0.910 0.660 Download
ECFP4 fingerprints 0.890 0.820 0.860 0.860 0.930 0.710 Download
ECFP6 fingerprints 0.850 0.840 0.840 0.840 0.930 0.680 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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