Target name

P08911: Muscarinic acetylcholine receptor M5


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P08911
GRCP SARfari Variant Name rCHRM5_1357
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 17
PharmGKB ID
KEGG ID rno:53949
Entrez Gene (Gene ID) 53949
BindingDB P08911

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.81 0.79 0.79 0.87 0.59 Download
FP4 fingerprints 0.840 0.760 0.800 0.810 0.860 0.600 Download
MACCS fingerprints 0.780 0.710 0.750 0.750 0.840 0.490 Download
Daylight fingerprints 0.640 0.720 0.680 0.670 0.750 0.360 Download
ECFP2 fingerprints 0.860 0.770 0.820 0.820 0.900 0.640 Download
ECFP4 fingerprints 0.890 0.790 0.840 0.850 0.910 0.690 Download
ECFP6 fingerprints 0.880 0.800 0.840 0.850 0.910 0.680 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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