Target name

P08912: Muscarinic acetylcholine receptor M5


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P08912
GRCP SARfari Variant Name hCHRM5_90
PDB ID
DrugBank ID DB00777 DB01142 DB00496 DB00321 DB00454 DB00934 DB01239 DB01238 DB00835 DB00568 DB00785 DB00408 DB06702 DB00376 DB00622 DB00540 DB00543 DB01151 DB00747 DB00334 DB00725 DB00726 DB01069 DB01403 DB08897 DB01036 DB00458 DB00572 DB01221 DB01224 DB00715 DB00363 DB00246 DB00340 DB00420 DB01591
BioGrid ID
GuidetoPHARMACOLOGY ID 17
PharmGKB ID PA26486
KEGG ID hsa:1133
Entrez Gene (Gene ID) 1133
BindingDB P08912

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.68 0.77 0.73 0.71 0.8 0.46 Download
FP4 fingerprints 0.750 0.640 0.690 0.710 0.770 0.390 Download
MACCS fingerprints 0.630 0.650 0.640 0.640 0.740 0.280 Download
Daylight fingerprints 0.630 0.870 0.750 0.710 0.800 0.510 Download
ECFP2 fingerprints 0.790 0.720 0.760 0.760 0.850 0.510 Download
ECFP4 fingerprints 0.820 0.790 0.810 0.810 0.890 0.610 Download
ECFP6 fingerprints 0.800 0.820 0.810 0.810 0.890 0.620 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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