Target name

P08913: Alpha-2A adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

  Database links

Uniprot primary ID P08913
GRCP SARfari Variant Name hA2AA_91
PDB ID 1HOF 1HOD 1HLL 1HO9
DrugBank ID DB00751 DB06148 DB01142 DB01049 DB04948 DB01624 DB00320 DB00321 DB01149 DB00734 DB00696 DB06694 DB00935 DB00934 DB00484 DB01365 DB01200 DB00449 DB01238 DB00633 DB00268 DB00852 DB06262 DB00408 DB00370 DB01136 DB01403 DB00668 DB00629 DB01018 DB00182 DB00543 DB00589 DB00968 DB00925 DB01151 DB01608 DB00334 DB06216 DB00865 DB00964 DB08815 DB06623 DB00800 DB00397 DB04855 DB01392 DB01186 DB01363 DB01267 DB00692 DB00726 DB00413 DB00217 DB00477 DB00540 DB00797 DB00697 DB00457 DB01224 DB00714 DB06711 DB00363 DB00246 DB00368 DB00248 DB00575 DB01577 DB00656
BioGrid ID 106659
GuidetoPHARMACOLOGY ID 25
PharmGKB ID PA35
KEGG ID hsa:150
Entrez Gene (Gene ID) 150
BindingDB P08913

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.55 0.87 0.71 0.66 0.82 0.45 Download
FP4 fingerprints 0.680 0.610 0.650 0.660 0.750 0.290 Download
MACCS fingerprints 0.690 0.670 0.680 0.680 0.750 0.350 Download
Daylight fingerprints 0.590 0.710 0.650 0.620 0.690 0.300 Download
ECFP2 fingerprints 0.850 0.720 0.790 0.800 0.880 0.580 Download
ECFP4 fingerprints 0.820 0.820 0.820 0.820 0.910 0.640 Download
ECFP6 fingerprints 0.770 0.830 0.800 0.790 0.900 0.590 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn