Target name

P10980: Muscarinic acetylcholine receptor M2


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity).

  Database links

Uniprot primary ID P10980
GRCP SARfari Variant Name rCHRM2_1361
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 14
PharmGKB ID
KEGG ID rno:81645
Entrez Gene (Gene ID) 81645
BindingDB P10980

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.79 0.79 0.78 0.85 0.57 Download
FP4 fingerprints 0.800 0.690 0.750 0.760 0.810 0.500 Download
MACCS fingerprints 0.730 0.680 0.700 0.710 0.790 0.410 Download
Daylight fingerprints 0.630 0.690 0.660 0.650 0.710 0.310 Download
ECFP2 fingerprints 0.880 0.750 0.820 0.830 0.890 0.640 Download
ECFP4 fingerprints 0.900 0.780 0.840 0.850 0.910 0.680 Download
ECFP6 fingerprints 0.880 0.800 0.840 0.850 0.910 0.680 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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