Target name

P11229: Muscarinic acetylcholine receptor M1

  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P11229
GRCP SARfari Variant Name hCHRM1_92
DrugBank ID DB00777 DB00979 DB01142 DB00771 DB00496 DB01591 DB00321 DB00670 DB01148 DB00454 DB00810 DB00568 DB04843 DB00280 DB00387 DB00477 DB00934 DB01151 DB01069 DB00875 DB01239 DB01238 DB00508 DB00245 DB00215 DB01231 DB00835 DB01233 DB00785 DB00408 DB06702 DB01403 DB00622 DB00185 DB00424 DB00540 DB00209 DB00420 DB00940 DB00376 DB00942 DB01175 DB00219 DB00332 DB00462 DB00747 DB00986 DB00334 DB00383 DB00725 DB01062 DB00202 DB00805 DB00804 DB00392 DB00726 DB01036 DB00354 DB00907 DB00809 DB01618 DB00458 DB00572 DB00517 DB00411 DB01221 DB01224 DB01085 DB00715 DB00782 DB00363 DB00246 DB00366 DB00434 DB00340 DB00543 DB01409 DB08897
BioGrid ID 107550
PharmGKB ID PA26484
KEGG ID hsa:1128
Entrez Gene (Gene ID) 1128
BindingDB P11229

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.73 0.72 0.73 0.73 0.8 0.45 Download
FP4 fingerprints 0.710 0.660 0.690 0.690 0.760 0.380 Download
MACCS fingerprints 0.690 0.620 0.660 0.670 0.740 0.310 Download
Daylight fingerprints 0.690 0.650 0.670 0.680 0.710 0.340 Download
ECFP2 fingerprints 0.810 0.760 0.780 0.790 0.870 0.570 Download
ECFP4 fingerprints 0.840 0.820 0.830 0.830 0.910 0.660 Download
ECFP6 fingerprints 0.840 0.830 0.840 0.840 0.900 0.670 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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