Target name

P13945: Beta-3 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

  Database links

Uniprot primary ID P13945
GRCP SARfari Variant Name hB3AR_93
PDB ID 2CDW
DrugBank ID DB01363 DB01288 DB00217 DB08808 DB01365 DB01407 DB01102 DB08807 DB00334 DB00321 DB00726 DB08893 DB00668 DB00368 DB00571 DB01064 DB00540 DB06262 DB00182
BioGrid ID 106664
GuidetoPHARMACOLOGY ID 30
PharmGKB ID PA24598
KEGG ID hsa:155
Entrez Gene (Gene ID) 155
BindingDB P13945

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.87 0.81 0.84 0.85 0.9 0.68 Download
FP4 fingerprints 0.920 0.750 0.830 0.840 0.880 0.670 Download
MACCS fingerprints 0.670 0.830 0.750 0.720 0.860 0.500 Download
Daylight fingerprints 0.840 0.800 0.820 0.820 0.860 0.640 Download
ECFP2 fingerprints 0.900 0.760 0.830 0.840 0.910 0.670 Download
ECFP4 fingerprints 0.900 0.810 0.860 0.860 0.920 0.720 Download
ECFP6 fingerprints 0.850 0.830 0.840 0.840 0.920 0.680 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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