Target name

P14416: D(2) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

  Database links

Uniprot primary ID P14416
GRCP SARfari Variant Name hDRD2_94
PDB ID 5AER 1I15
DrugBank ID DB00777 DB06148 DB01142 DB01063 DB01624 DB01100 DB01622 DB01069 DB00490 DB01621 DB04844 DB00568 DB04842 DB06216 DB00915 DB06288 DB00875 DB00502 DB00433 DB01239 DB01238 DB00714 DB01235 DB00831 DB00268 DB01049 DB00363 DB01233 DB00934 DB00409 DB00408 DB00370 DB01403 DB00623 DB00679 DB00540 DB00182 DB00420 DB00589 DB01614 DB01151 DB01267 DB01425 DB00334 DB05271 DB04946 DB00933 DB01043 DB00391 DB06144 DB01623 DB08815 DB01392 DB01618 DB01186 DB01200 DB00805 DB00458 DB00248 DB00726 DB00413 DB00696 DB00477 DB01224 DB00450 DB01221 DB00988 DB01184 DB00734 DB00508 DB00850 DB00246 DB00543 DB09018
BioGrid ID 108147
GuidetoPHARMACOLOGY ID 215
PharmGKB ID PA27478
KEGG ID hsa:1813
Entrez Gene (Gene ID) 1813
BindingDB P14416

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.77 0.71 0.74 0.75 0.82 0.48 Download
FP4 fingerprints 0.850 0.660 0.760 0.780 0.810 0.520 Download
MACCS fingerprints 0.820 0.590 0.710 0.740 0.770 0.420 Download
Daylight fingerprints 0.670 0.610 0.640 0.650 0.690 0.280 Download
ECFP2 fingerprints 0.880 0.720 0.800 0.820 0.870 0.610 Download
ECFP4 fingerprints 0.880 0.780 0.830 0.840 0.900 0.660 Download
ECFP6 fingerprints 0.830 0.810 0.820 0.820 0.890 0.640 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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