Target name

P14600: Substance-P receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

  Database links

Uniprot primary ID P14600
GRCP SARfari Variant Name rNK1R_1364
PDB ID
DrugBank ID
BioGrid ID 246930
GuidetoPHARMACOLOGY ID 360
PharmGKB ID
KEGG ID rno:24807
Entrez Gene (Gene ID) 24807
BindingDB P14600

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.87 0.79 0.83 0.84 0.87 0.66 Download
FP4 fingerprints 0.670 0.780 0.720 0.710 0.850 0.450 Download
MACCS fingerprints 0.670 0.690 0.680 0.670 0.790 0.350 Download
Daylight fingerprints 0.660 0.860 0.760 0.730 0.820 0.520 Download
ECFP2 fingerprints 0.700 0.830 0.760 0.750 0.870 0.530 Download
ECFP4 fingerprints 0.710 0.860 0.790 0.770 0.890 0.580 Download
ECFP6 fingerprints 0.670 0.890 0.780 0.750 0.900 0.570 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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