Target name

P14842: 5-hydroxytryptamine receptor 2A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca

  Database links

Uniprot primary ID P14842
GRCP SARfari Variant Name r5HT2A_1365
PDB ID 4OAJ
DrugBank ID
BioGrid ID 248227
GuidetoPHARMACOLOGY ID 6
PharmGKB ID
KEGG ID rno:29595
Entrez Gene (Gene ID) 29595
BindingDB P14842

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.71 0.78 0.79 0.85 0.56 Download
FP4 fingerprints 0.850 0.720 0.790 0.800 0.850 0.580 Download
MACCS fingerprints 0.780 0.680 0.730 0.740 0.800 0.450 Download
Daylight fingerprints 0.740 0.650 0.690 0.700 0.750 0.380 Download
ECFP2 fingerprints 0.870 0.780 0.830 0.840 0.910 0.660 Download
ECFP4 fingerprints 0.900 0.830 0.860 0.870 0.930 0.730 Download
ECFP6 fingerprints 0.860 0.840 0.850 0.850 0.930 0.700 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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