Target name

P15823: Alpha-1B adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).

  Database links

Uniprot primary ID P15823
GRCP SARfari Variant Name rA1AB_1367
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 23
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID)
BindingDB P15823

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.69 0.74 0.76 0.83 0.49 Download
FP4 fingerprints 0.780 0.650 0.710 0.730 0.790 0.430 Download
MACCS fingerprints 0.770 0.640 0.710 0.730 0.760 0.420 Download
Daylight fingerprints 0.710 0.640 0.680 0.690 0.720 0.350 Download
ECFP2 fingerprints 0.880 0.740 0.810 0.820 0.880 0.620 Download
ECFP4 fingerprints 0.880 0.800 0.840 0.850 0.910 0.680 Download
ECFP6 fingerprints 0.850 0.830 0.840 0.840 0.910 0.680 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn