Target name

P16610: Substance-K receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

  Database links

Uniprot primary ID P16610
GRCP SARfari Variant Name rNK2R_1370
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 361
PharmGKB ID
KEGG ID rno:25007
Entrez Gene (Gene ID) 25007
BindingDB P16610

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.97 0.78 0.88 0.89 0.89 0.77 Download
FP4 fingerprints 0.870 0.680 0.780 0.800 0.850 0.570 Download
MACCS fingerprints 0.900 0.740 0.820 0.830 0.860 0.650 Download
Daylight fingerprints 0.880 0.800 0.840 0.850 0.870 0.690 Download
ECFP2 fingerprints 0.910 0.780 0.850 0.860 0.870 0.700 Download
ECFP4 fingerprints 0.940 0.850 0.890 0.900 0.930 0.790 Download
ECFP6 fingerprints 0.910 0.900 0.910 0.910 0.940 0.810 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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