Target name

P18089: Alpha-2B adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

  Database links

Uniprot primary ID P18089
GRCP SARfari Variant Name hA2AB_96
PDB ID 2CVA
DrugBank ID DB06148 DB01142 DB01049 DB01365 DB00734 DB00696 DB06216 DB06694 DB00935 DB00934 DB00484 DB01200 DB01238 DB00268 DB06262 DB00408 DB01136 DB01403 DB00629 DB01018 DB00182 DB00543 DB00589 DB00925 DB01151 DB00668 DB00334 DB05271 DB00964 DB00800 DB00292 DB04855 DB01392 DB01186 DB01363 DB01267 DB00726 DB00413 DB00217 DB00477 DB00540 DB00797 DB00697 DB00457 DB01224 DB00714 DB00363 DB00246 DB00368 DB00248 DB00575 DB01577
BioGrid ID 106660
GuidetoPHARMACOLOGY ID 26
PharmGKB ID PA36
KEGG ID hsa:151
Entrez Gene (Gene ID) 151
BindingDB P18089

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.59 0.86 0.72 0.68 0.82 0.46 Download
FP4 fingerprints 0.610 0.670 0.640 0.620 0.740 0.270 Download
MACCS fingerprints 0.670 0.700 0.680 0.680 0.740 0.360 Download
Daylight fingerprints 0.560 0.890 0.730 0.670 0.770 0.480 Download
ECFP2 fingerprints 0.770 0.720 0.750 0.760 0.840 0.500 Download
ECFP4 fingerprints 0.770 0.810 0.790 0.790 0.890 0.580 Download
ECFP6 fingerprints 0.740 0.830 0.780 0.770 0.880 0.570 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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