Target name

P18090: Beta-1 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

  Database links

Uniprot primary ID P18090
GRCP SARfari Variant Name rB1AR_1371
PDB ID 2FF9
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 28
PharmGKB ID
KEGG ID rno:24925
Entrez Gene (Gene ID) 24925
BindingDB P18090

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.61 0.67 0.69 0.81 0.35 Download
FP4 fingerprints 0.700 0.560 0.630 0.650 0.720 0.270 Download
MACCS fingerprints 0.780 0.530 0.660 0.700 0.730 0.320 Download
Daylight fingerprints 0.720 0.550 0.640 0.670 0.700 0.280 Download
ECFP2 fingerprints 0.680 0.580 0.630 0.650 0.770 0.260 Download
ECFP4 fingerprints 0.800 0.710 0.750 0.760 0.840 0.510 Download
ECFP6 fingerprints 0.780 0.790 0.780 0.780 0.870 0.560 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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