Target name

P18130: Alpha-1A adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).

  Database links

Uniprot primary ID P18130
GRCP SARfari Variant Name bA1AA_1372
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:282134
Entrez Gene (Gene ID) 282134
BindingDB P18130

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.67 0.8 0.73 0.71 0.81 0.47 Download
FP4 fingerprints 0.750 0.580 0.660 0.690 0.740 0.330 Download
MACCS fingerprints 0.710 0.660 0.680 0.690 0.770 0.370 Download
Daylight fingerprints 0.620 0.690 0.660 0.640 0.740 0.310 Download
ECFP2 fingerprints 0.820 0.640 0.730 0.750 0.810 0.470 Download
ECFP4 fingerprints 0.910 0.750 0.830 0.840 0.900 0.670 Download
ECFP6 fingerprints 0.880 0.800 0.840 0.840 0.910 0.670 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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