Target name

P18825: Alpha-2C adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

  Database links

Uniprot primary ID P18825
GRCP SARfari Variant Name hA2AC_97
PDB ID
DrugBank ID DB06148 DB01142 DB01049 DB01365 DB00734 DB06694 DB00935 DB00934 DB00484 DB01200 DB04946 DB01238 DB00268 DB06262 DB00408 DB00370 DB01136 DB01403 DB00540 DB00182 DB00543 DB00589 DB00925 DB01151 DB00668 DB00334 DB06216 DB08815 DB00800 DB04855 DB01392 DB01186 DB01363 DB01267 DB00413 DB00217 DB00477 DB00797 DB00697 DB01224 DB00714 DB00363 DB00246 DB00368 DB00248 DB00575 DB01577
BioGrid ID 106661
GuidetoPHARMACOLOGY ID 27
PharmGKB ID PA37
KEGG ID hsa:152
Entrez Gene (Gene ID) 152
BindingDB P18825

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.56 0.87 0.72 0.67 0.84 0.46 Download
FP4 fingerprints 0.670 0.690 0.680 0.680 0.790 0.360 Download
MACCS fingerprints 0.710 0.710 0.710 0.710 0.790 0.420 Download
Daylight fingerprints 0.610 0.880 0.750 0.710 0.790 0.510 Download
ECFP2 fingerprints 0.830 0.760 0.790 0.800 0.880 0.580 Download
ECFP4 fingerprints 0.810 0.810 0.810 0.810 0.910 0.620 Download
ECFP6 fingerprints 0.760 0.840 0.800 0.790 0.900 0.610 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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