Target name

P19327: 5-hydroxytryptamine receptor 1A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca

  Database links

Uniprot primary ID P19327
GRCP SARfari Variant Name r5HT1A_1377
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 1
PharmGKB ID
KEGG ID rno:24473
Entrez Gene (Gene ID) 24473
BindingDB P19327

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.72 0.78 0.79 0.86 0.56 Download
FP4 fingerprints 0.850 0.720 0.780 0.790 0.860 0.570 Download
MACCS fingerprints 0.830 0.650 0.740 0.760 0.810 0.490 Download
Daylight fingerprints 0.730 0.720 0.720 0.720 0.770 0.440 Download
ECFP2 fingerprints 0.900 0.780 0.840 0.850 0.910 0.680 Download
ECFP4 fingerprints 0.910 0.850 0.880 0.880 0.940 0.760 Download
ECFP6 fingerprints 0.870 0.870 0.870 0.870 0.940 0.730 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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