Target name

P20309: Muscarinic acetylcholine receptor M3

  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P20309
GRCP SARfari Variant Name hCHRM3_98
DrugBank ID DB00777 DB01142 DB01062 DB00729 DB00496 DB01625 DB00321 DB00454 DB04843 DB00280 DB00387 DB00934 DB01069 DB00462 DB01239 DB01238 DB01231 DB00835 DB00568 DB00785 DB00408 DB06702 DB01338 DB01403 DB00622 DB00185 DB00424 DB00540 DB00420 DB00572 DB00376 DB01151 DB00332 DB00747 DB00986 DB00334 DB00383 DB00725 DB00726 DB00202 DB08897 DB01036 DB06709 DB00809 DB00458 DB01337 DB00517 DB00477 DB01221 DB01226 DB01224 DB01085 DB00715 DB00363 DB00246 DB00434 DB00340 DB00543 DB00193 DB01409 DB01591
BioGrid ID 107553
PharmGKB ID PA112
KEGG ID hsa:1131
Entrez Gene (Gene ID) 1131
BindingDB P20309

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.68 0.71 0.72 0.79 0.42 Download
FP4 fingerprints 0.730 0.670 0.700 0.710 0.760 0.400 Download
MACCS fingerprints 0.770 0.590 0.680 0.700 0.750 0.360 Download
Daylight fingerprints 0.790 0.690 0.740 0.750 0.800 0.480 Download
ECFP2 fingerprints 0.850 0.770 0.810 0.820 0.890 0.630 Download
ECFP4 fingerprints 0.850 0.830 0.840 0.840 0.920 0.680 Download
ECFP6 fingerprints 0.840 0.830 0.840 0.840 0.910 0.670 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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