Target name

P21451: Endothelin B receptor


  Protein function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P21451
GRCP SARfari Variant Name rETBR_1384
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 220
PharmGKB ID
KEGG ID rno:50672
Entrez Gene (Gene ID) 50672
BindingDB P21451

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.69 0.73 0.74 0.81 0.46 Download
FP4 fingerprints 0.750 0.730 0.740 0.740 0.740 0.480 Download
MACCS fingerprints 0.740 0.680 0.710 0.720 0.760 0.420 Download
Daylight fingerprints 0.730 0.730 0.730 0.730 0.770 0.460 Download
ECFP2 fingerprints 0.750 0.790 0.770 0.760 0.800 0.540 Download
ECFP4 fingerprints 0.750 0.810 0.780 0.780 0.850 0.570 Download
ECFP6 fingerprints 0.750 0.820 0.780 0.780 0.840 0.570 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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