Target name

P21452: Substance-K receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

  Database links

Uniprot primary ID P21452
GRCP SARfari Variant Name hNK2R_99
PDB ID
DrugBank ID
BioGrid ID 112728
GuidetoPHARMACOLOGY ID 361
PharmGKB ID PA36303
KEGG ID hsa:6865
Entrez Gene (Gene ID) 6865
BindingDB P21452

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.89 0.82 0.85 0.86 0.91 0.71 Download
FP4 fingerprints 0.850 0.830 0.840 0.840 0.910 0.680 Download
MACCS fingerprints 0.840 0.750 0.800 0.810 0.880 0.600 Download
Daylight fingerprints 0.860 0.870 0.860 0.860 0.900 0.730 Download
ECFP2 fingerprints 0.890 0.890 0.890 0.890 0.950 0.780 Download
ECFP4 fingerprints 0.900 0.920 0.910 0.910 0.970 0.820 Download
ECFP6 fingerprints 0.880 0.940 0.910 0.910 0.970 0.820 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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