Target name

P21453: Sphingosine 1-phosphate receptor 1

  Protein function

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

  Database links

Uniprot primary ID P21453
GRCP SARfari Variant Name hEDG1_100
DrugBank ID
BioGrid ID 108225
PharmGKB ID PA162402344
KEGG ID hsa:1901
Entrez Gene (Gene ID) 1901
BindingDB P21453

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.9 0.84 0.83 0.9 0.69 Download
FP4 fingerprints 0.770 0.800 0.780 0.780 0.850 0.570 Download
MACCS fingerprints 0.640 0.850 0.740 0.710 0.830 0.500 Download
Daylight fingerprints 0.720 0.770 0.740 0.740 0.790 0.490 Download
ECFP2 fingerprints 0.820 0.860 0.840 0.840 0.920 0.680 Download
ECFP4 fingerprints 0.860 0.900 0.880 0.880 0.940 0.760 Download
ECFP6 fingerprints 0.830 0.910 0.870 0.870 0.940 0.750 Download

  Download datasets

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Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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