Target name

P21554: Cannabinoid receptor 1


  Protein function

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca

  Database links

Uniprot primary ID P21554
GRCP SARfari Variant Name hCB1R_102
PDB ID 2KOE 1LVR 1LVQ 2B0Y
DrugBank ID DB00470 DB06155 DB00486
BioGrid ID 107668
GuidetoPHARMACOLOGY ID 56
PharmGKB ID PA26681
KEGG ID hsa:1268
Entrez Gene (Gene ID) 1268
BindingDB P21554

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.62 0.88 0.75 0.71 0.87 0.52 Download
FP4 fingerprints 0.790 0.740 0.760 0.770 0.840 0.530 Download
MACCS fingerprints 0.720 0.720 0.720 0.720 0.790 0.440 Download
Daylight fingerprints 0.710 0.670 0.690 0.690 0.720 0.370 Download
ECFP2 fingerprints 0.820 0.850 0.830 0.830 0.920 0.670 Download
ECFP4 fingerprints 0.860 0.890 0.870 0.870 0.940 0.750 Download
ECFP6 fingerprints 0.820 0.900 0.860 0.860 0.940 0.730 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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