Target name

P21728: D(1A) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

  Database links

Uniprot primary ID P21728
GRCP SARfari Variant Name hDRD1_103
PDB ID 1OZ5
DrugBank ID DB00777 DB06148 DB01063 DB01624 DB01608 DB01623 DB01621 DB00850 DB06216 DB00875 DB00502 DB01239 DB01238 DB00714 DB01235 DB01049 DB00568 DB00268 DB00408 DB00370 DB01403 DB00623 DB00679 DB00353 DB00420 DB00589 DB01614 DB01622 DB00334 DB05271 DB04946 DB00726 DB00805 DB00800 DB00397 DB00734 DB01186 DB01200 DB01267 DB00458 DB00248 DB00413 DB00696 DB00477 DB00988 DB01224 DB00508 DB00363 DB00246 DB00543
BioGrid ID 108146
GuidetoPHARMACOLOGY ID 214
PharmGKB ID PA147
KEGG ID hsa:1812
Entrez Gene (Gene ID) 1812
BindingDB P21728

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.69 0.89 0.79 0.76 0.87 0.59 Download
FP4 fingerprints 0.800 0.730 0.770 0.770 0.850 0.530 Download
MACCS fingerprints 0.780 0.730 0.750 0.760 0.850 0.510 Download
Daylight fingerprints 0.630 0.890 0.760 0.720 0.840 0.540 Download
ECFP2 fingerprints 0.860 0.770 0.820 0.820 0.890 0.630 Download
ECFP4 fingerprints 0.840 0.840 0.840 0.840 0.910 0.690 Download
ECFP6 fingerprints 0.820 0.880 0.850 0.850 0.910 0.700 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn