Target name

P21731: Thromboxane A2 receptor


  Protein function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform

  Database links

Uniprot primary ID P21731
GRCP SARfari Variant Name hTBXA2R_105
PDB ID 1LBN
DrugBank ID DB01207
BioGrid ID 112777
GuidetoPHARMACOLOGY ID 346
PharmGKB ID PA348
KEGG ID hsa:6915
Entrez Gene (Gene ID) 6915
BindingDB P21731

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.87 0.88 0.88 0.87 0.93 0.75 Download
FP4 fingerprints 0.910 0.790 0.850 0.850 0.910 0.700 Download
MACCS fingerprints 0.800 0.780 0.790 0.800 0.870 0.590 Download
Daylight fingerprints 0.760 0.800 0.780 0.780 0.840 0.560 Download
ECFP2 fingerprints 0.920 0.840 0.880 0.880 0.950 0.760 Download
ECFP4 fingerprints 0.920 0.890 0.910 0.910 0.960 0.820 Download
ECFP6 fingerprints 0.900 0.910 0.900 0.900 0.960 0.810 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn