Target name

P21917: D(4) dopamine receptor


  Protein function

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

  Database links

Uniprot primary ID P21917
GRCP SARfari Variant Name hDRD4_106
PDB ID
DrugBank ID DB00777 DB00734 DB04946 DB01238 DB01235 DB00268 DB00409 DB00408 DB01403 DB00543 DB00589 DB05271 DB00334 DB06216 DB00413 DB01200 DB01267 DB00248 DB01186 DB00477 DB00988 DB01224 DB00714 DB00363 DB00246 DB00420
BioGrid ID 108149
GuidetoPHARMACOLOGY ID 217
PharmGKB ID PA27480
KEGG ID hsa:1815
Entrez Gene (Gene ID) 1815
BindingDB P21917

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.67 0.75 0.76 0.82 0.5 Download
FP4 fingerprints 0.880 0.660 0.770 0.790 0.800 0.550 Download
MACCS fingerprints 0.830 0.650 0.740 0.760 0.800 0.480 Download
Daylight fingerprints 0.700 0.670 0.690 0.690 0.730 0.370 Download
ECFP2 fingerprints 0.890 0.720 0.800 0.820 0.870 0.610 Download
ECFP4 fingerprints 0.890 0.780 0.840 0.840 0.900 0.670 Download
ECFP6 fingerprints 0.850 0.800 0.830 0.830 0.900 0.650 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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