Target name

P22086: Alpha-2C adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

  Database links

Uniprot primary ID P22086
GRCP SARfari Variant Name rA2AC_1390
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 27
PharmGKB ID
KEGG ID rno:24175
Entrez Gene (Gene ID) 24175
BindingDB P22086

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.8 0.73 0.76 0.77 0.84 0.52 Download
FP4 fingerprints 0.750 0.650 0.700 0.710 0.780 0.400 Download
MACCS fingerprints 0.720 0.670 0.690 0.700 0.760 0.380 Download
Daylight fingerprints 0.660 0.690 0.680 0.670 0.730 0.350 Download
ECFP2 fingerprints 0.860 0.720 0.790 0.810 0.890 0.590 Download
ECFP4 fingerprints 0.880 0.780 0.830 0.840 0.930 0.670 Download
ECFP6 fingerprints 0.870 0.810 0.840 0.850 0.920 0.690 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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