Target name

P24530: Endothelin B receptor


  Protein function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P24530
GRCP SARfari Variant Name hETBR_110
PDB ID
DrugBank ID DB08932 DB00559 DB06268
BioGrid ID 108232
GuidetoPHARMACOLOGY ID 220
PharmGKB ID PA27618
KEGG ID hsa:1910
Entrez Gene (Gene ID) 1910
BindingDB P24530

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.72 0.9 0.81 0.79 0.91 0.64 Download
FP4 fingerprints 0.730 0.720 0.730 0.730 0.840 0.450 Download
MACCS fingerprints 0.860 0.770 0.810 0.820 0.870 0.630 Download
Daylight fingerprints 0.820 0.770 0.800 0.800 0.840 0.590 Download
ECFP2 fingerprints 0.840 0.830 0.830 0.830 0.920 0.670 Download
ECFP4 fingerprints 0.860 0.900 0.880 0.880 0.940 0.760 Download
ECFP6 fingerprints 0.830 0.920 0.870 0.870 0.930 0.750 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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