Target name

P25021: Histamine H2 receptor


  Protein function

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

  Database links

Uniprot primary ID P25021
GRCP SARfari Variant Name hHRH2_111
PDB ID
DrugBank ID DB00751 DB00501 DB00334 DB00863 DB01142 DB00667 DB00927 DB00797 DB08806 DB06216 DB00321 DB00585 DB00408 DB00940 DB00272
BioGrid ID
GuidetoPHARMACOLOGY ID 263
PharmGKB ID PA29457
KEGG ID hsa:3274
Entrez Gene (Gene ID) 3274
BindingDB P25021

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.65 0.81 0.73 0.71 0.76 0.47 Download
FP4 fingerprints 0.520 0.730 0.630 0.580 0.660 0.260 Download
MACCS fingerprints 0.560 0.710 0.640 0.610 0.680 0.280 Download
Daylight fingerprints 0.460 0.780 0.620 0.550 0.680 0.250 Download
ECFP2 fingerprints 0.600 0.740 0.670 0.650 0.720 0.340 Download
ECFP4 fingerprints 0.710 0.830 0.770 0.750 0.820 0.540 Download
ECFP6 fingerprints 0.720 0.830 0.780 0.760 0.830 0.560 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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