Target name

P25024: C-X-C chemokine receptor type 1


  Protein function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

  Database links

Uniprot primary ID P25024
GRCP SARfari Variant Name hIL8RA_112
PDB ID 2LNL 1ILP 1ILQ
DrugBank ID DB01009
BioGrid ID 109791
GuidetoPHARMACOLOGY ID 68
PharmGKB ID PA29842
KEGG ID hsa:3577
Entrez Gene (Gene ID) 3577
BindingDB P25024

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.93 0.83 0.81 0.93 0.68 Download
FP4 fingerprints 0.780 0.940 0.860 0.850 0.910 0.730 Download
MACCS fingerprints 0.760 0.890 0.820 0.810 0.900 0.650 Download
Daylight fingerprints 0.660 0.980 0.820 0.790 0.900 0.680 Download
ECFP2 fingerprints 0.800 0.910 0.850 0.840 0.930 0.710 Download
ECFP4 fingerprints 0.830 0.910 0.870 0.870 0.940 0.750 Download
ECFP6 fingerprints 0.870 0.900 0.890 0.880 0.950 0.770 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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