Target name

P25025: C-X-C chemokine receptor type 2


  Protein function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

  Database links

Uniprot primary ID P25025
GRCP SARfari Variant Name hIL8RB_113
PDB ID 4Q3H
DrugBank ID
BioGrid ID 109793
GuidetoPHARMACOLOGY ID 69
PharmGKB ID PA29843
KEGG ID hsa:3579
Entrez Gene (Gene ID) 3579
BindingDB P25025

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.94 0.89 0.88 0.96 0.78 Download
FP4 fingerprints 0.880 0.910 0.900 0.890 0.960 0.790 Download
MACCS fingerprints 0.780 0.880 0.830 0.830 0.900 0.670 Download
Daylight fingerprints 0.680 0.980 0.830 0.800 0.930 0.690 Download
ECFP2 fingerprints 0.940 0.930 0.930 0.930 0.970 0.860 Download
ECFP4 fingerprints 0.950 0.940 0.950 0.950 0.970 0.890 Download
ECFP6 fingerprints 0.950 0.940 0.950 0.950 0.970 0.900 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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