Target name

P25100: Alpha-1D adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

  Database links

Uniprot primary ID P25100
GRCP SARfari Variant Name hA1AD_116
PDB ID
DrugBank ID DB00777 DB06148 DB00598 DB01142 DB01049 DB06207 DB00590 DB00321 DB06144 DB00696 DB01162 DB00388 DB06694 DB00935 DB06262 DB00934 DB00370 DB01136 DB01403 DB00622 DB00706 DB00540 DB00182 DB00420 DB00925 DB01151 DB00668 DB00723 DB00211 DB00800 DB04855 DB00298 DB01200 DB00458 DB00248 DB01186 DB01365 DB00477 DB00575 DB00457 DB01224 DB00368 DB00543 DB00346
BioGrid ID 106656
GuidetoPHARMACOLOGY ID 24
PharmGKB ID PA24597
KEGG ID hsa:146
Entrez Gene (Gene ID) 146
BindingDB P25100

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.65 0.87 0.76 0.73 0.85 0.53 Download
FP4 fingerprints 0.750 0.710 0.730 0.730 0.800 0.460 Download
MACCS fingerprints 0.680 0.740 0.710 0.700 0.790 0.420 Download
Daylight fingerprints 0.710 0.780 0.750 0.740 0.840 0.490 Download
ECFP2 fingerprints 0.760 0.800 0.780 0.770 0.890 0.550 Download
ECFP4 fingerprints 0.760 0.880 0.820 0.800 0.920 0.640 Download
ECFP6 fingerprints 0.740 0.900 0.820 0.800 0.920 0.650 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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