Target name

P25101: Endothelin-1 receptor


  Protein function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

  Database links

Uniprot primary ID P25101
GRCP SARfari Variant Name hETA_117
PDB ID
DrugBank ID DB08932 DB00945 DB00559 DB06268
BioGrid ID 108231
GuidetoPHARMACOLOGY ID 219
PharmGKB ID PA27617
KEGG ID hsa:1909
Entrez Gene (Gene ID) 1909
BindingDB P25101

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.92 0.88 0.87 0.94 0.76 Download
FP4 fingerprints 0.840 0.840 0.840 0.840 0.920 0.680 Download
MACCS fingerprints 0.740 0.840 0.790 0.780 0.900 0.590 Download
Daylight fingerprints 0.850 0.770 0.810 0.810 0.860 0.620 Download
ECFP2 fingerprints 0.930 0.880 0.910 0.910 0.960 0.820 Download
ECFP4 fingerprints 0.940 0.900 0.920 0.920 0.960 0.840 Download
ECFP6 fingerprints 0.920 0.910 0.920 0.920 0.960 0.830 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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