Target name

P25103: Substance-P receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

  Database links

Uniprot primary ID P25103
GRCP SARfari Variant Name hNK1R_118
PDB ID 2KS9 2KSB 2KSA
DrugBank ID DB04894 DB01221 DB00673
BioGrid ID 112732
GuidetoPHARMACOLOGY ID 360
PharmGKB ID PA36302
KEGG ID hsa:6869
Entrez Gene (Gene ID) 6869
BindingDB P25103

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.85 0.75 0.8 0.81 0.9 0.61 Download
FP4 fingerprints 0.790 0.790 0.790 0.790 0.870 0.580 Download
MACCS fingerprints 0.800 0.730 0.760 0.770 0.850 0.530 Download
Daylight fingerprints 0.800 0.790 0.790 0.800 0.850 0.590 Download
ECFP2 fingerprints 0.900 0.880 0.890 0.890 0.960 0.790 Download
ECFP4 fingerprints 0.910 0.920 0.920 0.920 0.970 0.830 Download
ECFP6 fingerprints 0.900 0.930 0.920 0.910 0.970 0.830 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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