Target name

P25105: Platelet-activating factor receptor


  Protein function

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P25105
GRCP SARfari Variant Name hPAFR_119
PDB ID 2B0X
DrugBank ID
BioGrid ID 111696
GuidetoPHARMACOLOGY ID 334
PharmGKB ID PA33933
KEGG ID hsa:5724
Entrez Gene (Gene ID) 5724
BindingDB P25105

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.73 0.91 0.82 0.8 0.93 0.65 Download
FP4 fingerprints 0.750 0.800 0.780 0.770 0.870 0.560 Download
MACCS fingerprints 0.820 0.720 0.770 0.780 0.840 0.540 Download
Daylight fingerprints 0.660 0.740 0.700 0.690 0.760 0.410 Download
ECFP2 fingerprints 0.930 0.890 0.910 0.910 0.960 0.820 Download
ECFP4 fingerprints 0.920 0.910 0.910 0.920 0.970 0.830 Download
ECFP6 fingerprints 0.910 0.910 0.910 0.910 0.970 0.810 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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